Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

Honda, Yoko; Ushigome, Fumihiko; Koyabu, Noriko; Morimoto, Satoshi; Shoyama, Yukihiro; Uchiumi, Takeshi; Kuwano, Michihiko; Ohtani, Hisakazu; Sawada, Yasufumi

Honda, Yoko; Ushigome, Fumihiko; Koyabu, Noriko; Morimoto, Satoshi; Shoyama, Yukihiro; Uchiumi, Takeshi; Kuwano, Michihiko; Ohtani, Hisakazu; Sawada, Yasufumi.

Affiliation

Honda Y; Department of Medico-Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Br J Pharmacol ; 143(7): 856-64, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15504753

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Beverages; Citrus/chemistry; Membrane Transport Proteins/metabolism; Multidrug Resistance-Associated Proteins/metabolism; Algorithms; Antineoplastic Agents, Phytogenic/pharmacokinetics; Biological Transport, Active/drug effects; Caco-2 Cells; Calcium Channel Blockers/pharmacology; Cyclosporine/pharmacology; Food-Drug Interactions; HIV Protease Inhibitors/pharmacokinetics; Humans; Immunosuppressive Agents/pharmacology; Membrane Transport Proteins/genetics; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins/genetics; Plant Extracts/chemistry; Propionates/pharmacology; Quinolines/pharmacology; Saquinavir/pharmacokinetics; Transfection; Verapamil/pharmacology; Vinblastine/pharmacokinetics

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Full text: 1 Database: MEDLINE Main subject: Membrane Transport Proteins / Beverages / Citrus / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Multidrug Resistance-Associated Proteins Language: En Journal: Br J Pharmacol Year: 2004 Type: Article Affiliation country: Japan

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