Electropharmacological effects of a spironolactone derivative, potassium canrenoate, assessed in the halothane-anesthetized canine model.

Sugiyama, Atsushi; Satoh, Yoshioki; Takahara, Akira; Ando, Kentaro; Wang, Kai; Honsho, Sachiko; Nakamura, Yuji; Hashimoto, Keitaro

Sugiyama, Atsushi; Satoh, Yoshioki; Takahara, Akira; Ando, Kentaro; Wang, Kai; Honsho, Sachiko; Nakamura, Yuji; Hashimoto, Keitaro.

Affiliation

Sugiyama A; Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho-cho, Nakakoma-gun, Yamanashi 409-3898, Japan. atsushis@yamanashi.ac.jp

J Pharmacol Sci ; 96(4): 436-43, 2004 Dec.

Article in En | MEDLINE | ID: mdl-15599107

Subject(s)

Canrenoic Acid/pharmacology; Heart/drug effects; Mineralocorticoid Receptor Antagonists/pharmacology; Action Potentials/drug effects; Anesthesia; Animals; Blood Pressure/drug effects; Canrenoic Acid/blood; Dogs; Electrocardiography/drug effects; Female; Halothane/pharmacology; Heart/physiology; Heart Rate/drug effects; Male; Refractory Period, Electrophysiological/drug effects

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Database: MEDLINE Main subject: Canrenoic Acid / Mineralocorticoid Receptor Antagonists / Heart Language: En Journal: J Pharmacol Sci Year: 2004 Type: Article Affiliation country: Japan

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