IL-8 enhancement of amyloid-beta (Abeta 1-42)-induced expression and production of pro-inflammatory cytokines and COX-2 in cultured human microglia.

Franciosi, Sonia; Choi, Hyun B; Kim, Seung U; McLarnon, James G

Franciosi, Sonia; Choi, Hyun B; Kim, Seung U; McLarnon, James G.

Affiliation

Franciosi S; Department of Pharmacology and Therapeutics, University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.

J Neuroimmunol ; 159(1-2): 66-74, 2005 Feb.

Article in En | MEDLINE | ID: mdl-15652404

Subject(s)

Adjuvants, Immunologic/physiology; Amyloid beta-Peptides/pharmacology; Cytokines/biosynthesis; Inflammation Mediators/metabolism; Interleukin-8/physiology; Microglia/enzymology; Microglia/immunology; Peptide Fragments/pharmacology; Prostaglandin-Endoperoxide Synthases/biosynthesis; Adjuvants, Immunologic/genetics; Adjuvants, Immunologic/pharmacology; Cells, Cultured; Cyclooxygenase 2; Drug Combinations; Fetus; Humans; Interleukin-1/biosynthesis; Interleukin-1/genetics; Interleukin-1/metabolism; Interleukin-10/biosynthesis; Interleukin-10/genetics; Interleukin-6/biosynthesis; Interleukin-6/genetics; Interleukin-6/metabolism; Interleukin-8/genetics; Interleukin-8/pharmacology; Membrane Proteins; Microglia/cytology; Microglia/metabolism; Prostaglandin-Endoperoxide Synthases/genetics; Transforming Growth Factor beta/biosynthesis; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta1; Tumor Necrosis Factor-alpha/biosynthesis; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism; Up-Regulation/immunology

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Peptide Fragments / Adjuvants, Immunologic / Amyloid beta-Peptides / Cytokines / Interleukin-8 / Prostaglandin-Endoperoxide Synthases / Microglia / Inflammation Mediators Language: En Journal: J Neuroimmunol Year: 2005 Type: Article

Search on Google

Add to My VHL

XML

PubMed Links