Hypothalamic K(ATP) channels control hepatic glucose production.

Pocai, Alessandro; Lam, Tony K T; Gutierrez-Juarez, Roger; Obici, Silvana; Schwartz, Gary J; Bryan, Joseph; Aguilar-Bryan, Lydia; Rossetti, Luciano

Pocai, Alessandro; Lam, Tony K T; Gutierrez-Juarez, Roger; Obici, Silvana; Schwartz, Gary J; Bryan, Joseph; Aguilar-Bryan, Lydia; Rossetti, Luciano.

Affiliation

Pocai A; Department of Medicine, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Nature ; 434(7036): 1026-31, 2005 Apr 21.

Article in En | MEDLINE | ID: mdl-15846348

Subject(s)

Adenosine Triphosphate/metabolism; Gluconeogenesis; Glucose/biosynthesis; Hypothalamus/metabolism; Liver/metabolism; Potassium Channels/metabolism; ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Animals; Diabetes Mellitus, Type 2/metabolism; Diabetes Mellitus, Type 2/physiopathology; Glucose/metabolism; Hyperinsulinism/metabolism; Hyperinsulinism/physiopathology; Insulin/metabolism; Liver/innervation; Male; Mice; Multidrug Resistance-Associated Proteins/deficiency; Multidrug Resistance-Associated Proteins/genetics; Multidrug Resistance-Associated Proteins/metabolism; Potassium Channels/chemistry; Potassium Channels/genetics; Potassium Channels, Inwardly Rectifying/genetics; Potassium Channels, Inwardly Rectifying/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sulfonylurea Receptors; Vagus Nerve/physiology

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Database: MEDLINE Main subject: Potassium Channels / Adenosine Triphosphate / Gluconeogenesis / Glucose / Hypothalamus / Liver Type of study: Risk_factors_studies Language: En Journal: Nature Year: 2005 Type: Article Affiliation country: United States

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