The 44 kDa Pim-1 kinase directly interacts with tyrosine kinase Etk/BMX and protects human prostate cancer cells from apoptosis induced by chemotherapeutic drugs.

Xie, Y; Xu, K; Dai, B; Guo, Z; Jiang, T; Chen, H; Qiu, Y

Xie, Y; Xu, K; Dai, B; Guo, Z; Jiang, T; Chen, H; Qiu, Y.

Affiliation

Xie Y; Department of Pharmacology & Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Oncogene ; 25(1): 70-8, 2006 Jan 05.

Article in En | MEDLINE | ID: mdl-16186805

Subject(s)

Antineoplastic Agents/pharmacology; Apoptosis; Gene Expression Regulation, Neoplastic; Prostatic Neoplasms/drug therapy; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins c-pim-1/physiology; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; COS Cells; Cell Line, Tumor; Cell Membrane/metabolism; Cell Nucleus/metabolism; Chlorocebus aethiops; Cytosol/metabolism; DNA, Complementary/metabolism; Down-Regulation; Doxorubicin/pharmacology; Expressed Sequence Tags; Genetic Vectors; Glutathione Transferase/metabolism; Humans; Immunohistochemistry; Immunoprecipitation; Interleukin-6/metabolism; Lentivirus/metabolism; Male; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Sequence Data; Phosphorylation; Plasmids/metabolism; Prostatic Neoplasms/metabolism; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins c-pim-1/metabolism; Sequence Homology, Amino Acid; Time Factors; Transfection; Tumor Suppressor Protein p53/metabolism

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Database: MEDLINE Main subject: Prostatic Neoplasms / Protein-Tyrosine Kinases / Gene Expression Regulation, Neoplastic / Apoptosis / Proto-Oncogene Proteins c-pim-1 / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: Oncogene Year: 2006 Type: Article Affiliation country: United States

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