Copper chelation with tetrathiomolybdate suppresses adjuvant-induced arthritis and inflammation-associated cachexia in rats.

Omoto, Atsushi; Kawahito, Yutaka; Prudovsky, Igor; Tubouchi, Yasunori; Kimura, Mizuho; Ishino, Hidetaka; Wada, Makoto; Yoshida, Makie; Kohno, Masataka; Yoshimura, Rikio; Yoshikawa, Toshikazu; Sano, Hajime

Omoto, Atsushi; Kawahito, Yutaka; Prudovsky, Igor; Tubouchi, Yasunori; Kimura, Mizuho; Ishino, Hidetaka; Wada, Makoto; Yoshida, Makie; Kohno, Masataka; Yoshimura, Rikio; Yoshikawa, Toshikazu; Sano, Hajime.

Affiliation

Omoto A; Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. omochan@koto.kpu-m.ac.jp

Arthritis Res Ther ; 7(6): R1174-82, 2005.

Article in En | MEDLINE | ID: mdl-16277669

Subject(s)

Arthritis, Experimental/drug therapy; Cachexia/drug therapy; Chelating Agents/therapeutic use; Chelation Therapy; Copper/metabolism; Molybdenum/therapeutic use; Administration, Oral; Animals; Arthritis, Experimental/complications; Arthritis, Experimental/pathology; Biomarkers/metabolism; Cachexia/complications; Cachexia/pathology; Disease Models, Animal; Female; Hindlimb/pathology; Immunoenzyme Techniques; Joints/drug effects; Joints/metabolism; Joints/pathology; Rats; Rats, Inbred Lew; Synovial Membrane/drug effects; Synovial Membrane/metabolism; Synovial Membrane/pathology; Vascular Endothelial Growth Factor A/blood

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Full text: 1 Database: MEDLINE Main subject: Arthritis, Experimental / Cachexia / Chelation Therapy / Chelating Agents / Copper / Molybdenum Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Arthritis Res Ther Year: 2005 Type: Article Affiliation country: Japan

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