Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in rats.
Am J Transplant
; 5(12): 2862-9, 2005 Dec.
Article
in En
| MEDLINE
| ID: mdl-16302998
ABSTRACT
Cardiac complications stemming from intra-cranial hypertension may result from impaired intra-cellular Ca(2+) homeostasis. The aim of this study was to examine the effects of dantrolene, a blocker of sarcoplasmic reticulum (SR) Ca(2+) release, on myocardial dysfunction associated with intra-cranial hypertension in rats. Dantrolene (10 mg) with and without 15% mannitol was administered to halothane-anesthetized rats prior to induction of intra-cranial hypertension by subdural balloon inflation. Its effects were compared to 3% and 15% mannitol and 5% Pentaspan. Dantrolene with mannitol or 15% mannitol alone prevented the transient intra-cranial hypertension-induced hyperdynamic response and ensuing circulatory collapse that was found in animals pre-treated with 3% mannitol solution or pentaspan. Moreover, hemodynamic function was preserved irrespective of TnI cleavage. However, only animals treated with high dose 15% mannitol exhibited lower lipid peroxidation content in the heart. In contrast, pre-treatment with dantrolene alone did not prevent the cardiac complications associated with intra-cranial hypertension. In conclusion, 15% mannitol attenuated the cardiopulmonary complications associated with intra-cranial hypertension. Dantrolene without mannitol was without effect. Since mannitol exhibits free radical scavenging properties, protection could be the result of a decrease in oxidative stress after intra-cranial hypertension.
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Database:
MEDLINE
Main subject:
Tissue Donors
/
Intracranial Hypertension
/
Dantrolene
/
Diuretics, Osmotic
/
Mannitol
/
Muscle Relaxants, Central
/
Cardiomyopathies
Type of study:
Etiology_studies
Language:
En
Journal:
Am J Transplant
Year:
2005
Type:
Article
Affiliation country:
Canada