[Study on anti-cancer components of Fig residues with supper critical fluid CO2 extracting technique].
Zhongguo Zhong Yao Za Zhi
; 30(18): 1443-7, 2005 Sep.
Article
in Zh
| MEDLINE
| ID: mdl-16381468
ABSTRACT
OBJECTIVE:
To optimize Supper Critical CO2 extracting technical (SFE-CO2) methods for extraction of anti-cancer active components of Fig Residues and to investigate the anti-cancer effect of the extract in vitro and in vivo.METHOD:
The anti-cancer activity of extracted compound was measured on U937,95D and AGS cancer cells in vitro by MTT method. The anti-cancer effect of the extraction of Fig Residues was studied on mice transplant liver cancer in vivo.RESULT:
The SFE-CO2 condition for extraction of the anti-cancer components of Fig Residues was optimized as follows granularity was 100, the extraction pressure was 30 MPa, the extraction temperature was 45 degrees C, the extraction time was 6 h and the CO2 flux was 12 L x h(-1); The IC50 of anti-cancer active components of Fig Residues on U937, 95D and AGS cells were 70.125 microg x mL(-1), 127.957 microg x mL(-1), 116.000 microg x mL(-1); The anti-cancer active components of Fig Residues inhibited 49.3% of the transplanted liver cancer in the mice.CONCLUSION:
The method for extracting the anticancer active components of Fig Residues is stable and reasonable, and the extract from Fig Residues is of the anticancer effect.
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Database:
MEDLINE
Traditional Medicines:
Medicinas_tradicionales_de_asia
/
Medicina_china
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Drugs, Chinese Herbal
/
Ficus
/
Liver Neoplasms
/
Antineoplastic Agents, Phytogenic
Language:
Zh
Journal:
Zhongguo Zhong Yao Za Zhi
Year:
2005
Type:
Article
Affiliation country:
China