Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo.

Taguchi, T; Takao, T; Iwasaki, Y; Nishiyama, M; Asaba, K; Hashimoto, K

Taguchi, T; Takao, T; Iwasaki, Y; Nishiyama, M; Asaba, K; Hashimoto, K.

Affiliation

Taguchi T; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Oko-cho, Kohasu, Nankoku 783-8505, Japan. tagu@muse.ocn.ne.jp

J Endocrinol ; 188(2): 321-31, 2006 Feb.

Article in En | MEDLINE | ID: mdl-16461558

Subject(s)

Adjuvants, Immunologic/pharmacology; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Dehydroepiandrosterone/pharmacology; NF-kappa B/antagonists & inhibitors; Pituitary Neoplasms/physiopathology; Sesquiterpenes/pharmacology; Animals; Apoptosis/drug effects; Corticosterone/blood; Estradiol/pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Immunohistochemistry/methods; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins/analysis; Pro-Opiomelanocortin/genetics; RNA, Messenger/analysis; RNA, Neoplasm/analysis; Repressor Proteins; Survivin; Testosterone/pharmacology; Transcription, Genetic/genetics; Tumor Cells, Cultured

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Database: MEDLINE Main subject: Pituitary Neoplasms / Sesquiterpenes / Adjuvants, Immunologic / Anti-Inflammatory Agents, Non-Steroidal / NF-kappa B / Dehydroepiandrosterone Language: En Journal: J Endocrinol Year: 2006 Type: Article Affiliation country: Japan

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