Aminopeptidase p mediated detoxification of organophosphonate analogues of sarin: mechanistic and stereochemical study at the phosphorus atom of the substrate.

Huang, Li-Fang; Su, Benson; Jao, Shu-Chuan; Liu, Kwang-Ting; Li, Wen-Shan

Huang, Li-Fang; Su, Benson; Jao, Shu-Chuan; Liu, Kwang-Ting; Li, Wen-Shan.

Affiliation

Huang LF; Institute of Chemistry, Academia Sinica, 128 Academia Road Sec. 2, Taipei 115, Taiwan.

Chembiochem ; 7(3): 506-14, 2006 Mar.

Article in En | MEDLINE | ID: mdl-16470765

Subject(s)

Aminopeptidases/metabolism; Phosphorus/chemistry; Sarin/metabolism; Aminopeptidases/genetics; Aminopeptidases/isolation & purification; Base Sequence; Catalysis; Crystallography, X-Ray; DNA Primers; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Organophosphorus Compounds/chemistry; Organophosphorus Compounds/metabolism; Sarin/analogs & derivatives; Sarin/chemistry; Stereoisomerism

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Database: MEDLINE Main subject: Phosphorus / Sarin / Aminopeptidases Language: En Journal: Chembiochem Year: 2006 Type: Article Affiliation country: Taiwan

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Database: MEDLINE Main subject: Phosphorus / Sarin / Aminopeptidases Language: En Journal: Chembiochem Year: 2006 Type: Article Affiliation country: Taiwan