Neuroprotective effects of ebselen are associated with the regulation of Bcl-2 and Bax proteins in cultured mouse cortical neurons.

Xu, Jie-Hua; Hu, Hai-Tao; Liu, Yong; Qian, Yi-Hua; Liu, Zhao-Hui; Tan, Qing-Rong; Zhang, Zhang-Jin

Xu, Jie-Hua; Hu, Hai-Tao; Liu, Yong; Qian, Yi-Hua; Liu, Zhao-Hui; Tan, Qing-Rong; Zhang, Zhang-Jin.

Affiliation

Xu JH; Department of Human Anatomy and Histoembryology, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Neurosci Lett ; 399(3): 210-4, 2006 May 22.

Article in En | MEDLINE | ID: mdl-16513270

Subject(s)

Azoles/pharmacology; Cerebral Cortex/cytology; Neurons/drug effects; Neuroprotective Agents/pharmacology; Organoselenium Compounds/pharmacology; Proto-Oncogene Proteins c-bcl-2/metabolism; bcl-2-Associated X Protein/metabolism; Analysis of Variance; Animals; Apoptosis/drug effects; Cell Count/methods; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Gene Expression Regulation, Developmental/drug effects; Glutamic Acid/adverse effects; Isoindoles; Mice; Neurons/metabolism; Time Factors

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Database: MEDLINE Main subject: Azoles / Cerebral Cortex / Organoselenium Compounds / Neuroprotective Agents / Proto-Oncogene Proteins c-bcl-2 / Bcl-2-Associated X Protein / Neurons Type of study: Risk_factors_studies Language: En Journal: Neurosci Lett Year: 2006 Type: Article Affiliation country: China

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