Bis(allixinato)oxovanadium(IV) complex is a potent antidiabetic agent: studies on structure-activity relationship for a series of hydroxypyrone-vanadium complexes.

Adachi, Yusuke; Yoshida, Jiro; Kodera, Yukihiro; Katoh, Akira; Takada, Jitsuya; Sakurai, Hiromu

Adachi, Yusuke; Yoshida, Jiro; Kodera, Yukihiro; Katoh, Akira; Takada, Jitsuya; Sakurai, Hiromu.

Affiliation

Adachi Y; Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan.

J Med Chem ; 49(11): 3251-6, 2006 Jun 01.

Article in En | MEDLINE | ID: mdl-16722643

Subject(s)

Hypoglycemic Agents/chemical synthesis; Organometallic Compounds/chemical synthesis; Pyrones/chemistry; Vanadium; Adipocytes/drug effects; Adipocytes/metabolism; Animals; Diabetes Mellitus, Experimental/drug therapy; Diabetes Mellitus, Type 1/drug therapy; Fatty Acids, Nonesterified/antagonists & inhibitors; Garlic; Hypoglycemic Agents/chemistry; Hypoglycemic Agents/pharmacology; In Vitro Techniques; Mice; Organometallic Compounds/chemistry; Organometallic Compounds/pharmacology; Rats; Structure-Activity Relationship

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Database: MEDLINE Main subject: Organometallic Compounds / Pyrones / Vanadium / Hypoglycemic Agents Language: En Journal: J Med Chem Year: 2006 Type: Article Affiliation country: Japan

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