Valproate blocks high-dose methamphetamine-induced behavioral cross-sensitization to locomotion-inducing effect of dizocilpine (MK-801), but not methamphetamine.

Ito, K; Abekawa, T; Koyama, T

Ito, K; Abekawa, T; Koyama, T.

Affiliation

Ito K; Department of Psychiatry, Hokkaido University, Graduate School of Medicine, Kita 15, Nishi 7, Sapporo, 060-8638, Japan. itokoki@med.hokudai.ac.jp

Psychopharmacology (Berl) ; 186(4): 525-33, 2006 Jul.

Article in En | MEDLINE | ID: mdl-16758239

Subject(s)

Anticonvulsants/pharmacology; Behavior, Animal/drug effects; Central Nervous System Stimulants/pharmacology; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Locomotion/drug effects; Methamphetamine/pharmacology; Valproic Acid/pharmacology; Animals; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid/metabolism; Male; Microdialysis; Neuronal Plasticity/drug effects; Nucleus Accumbens/drug effects; Nucleus Accumbens/metabolism; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/metabolism; Time Factors

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Database: MEDLINE Main subject: Behavior, Animal / Dizocilpine Maleate / Valproic Acid / Excitatory Amino Acid Antagonists / Central Nervous System Stimulants / Locomotion / Methamphetamine / Anticonvulsants Language: En Journal: Psychopharmacology (Berl) Year: 2006 Type: Article Affiliation country: Japan

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