Solid-phase synthesis and structure-activity relationships of novel biarylethers as melanin-concentrating hormone receptor-1 antagonists.

Ma, Vu; Bannon, Anthony W; Baumgartner, Jamie; Hale, Clarence; Hsieh, Faye; Hulme, Christopher; Rorrer, Kirk; Salon, John; van Staden, Carlo; Tempest, Paul

Ma, Vu; Bannon, Anthony W; Baumgartner, Jamie; Hale, Clarence; Hsieh, Faye; Hulme, Christopher; Rorrer, Kirk; Salon, John; van Staden, Carlo; Tempest, Paul.

Affiliation

Ma V; Chemistry Research and Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. vma@amgen.com

Bioorg Med Chem Lett ; 16(19): 5066-72, 2006 Oct 01.

Article in En | MEDLINE | ID: mdl-16887348

Subject(s)

Ethers/chemical synthesis; Receptors, Pituitary Hormone/antagonists & inhibitors; Receptors, Somatostatin/antagonists & inhibitors; Combinatorial Chemistry Techniques; Drug Evaluation, Preclinical; Ethers/pharmacology; Humans; Inhibitory Concentration 50; Obesity/drug therapy; Structure-Activity Relationship

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Receptors, Pituitary Hormone / Receptors, Somatostatin / Ethers Language: En Journal: Bioorg Med Chem Lett Year: 2006 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links