A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours.

Nakagawa, K; Kudoh, S; Matsui, K; Negoro, S; Yamamoto, N; Latz, J E; Adachi, S; Fukuoka, M

Nakagawa, K; Kudoh, S; Matsui, K; Negoro, S; Yamamoto, N; Latz, J E; Adachi, S; Fukuoka, M.

Affiliation

Nakagawa K; Kinki University School of Medicine, Osakasayama, 589-8511, Japan. nakagawa@med.kindai.ac.jp

Br J Cancer ; 95(6): 677-82, 2006 Sep 18.

Article in En | MEDLINE | ID: mdl-16940981

Subject(s)

Antineoplastic Agents/administration & dosage; Folic Acid/administration & dosage; Glutamates/administration & dosage; Guanine/analogs & derivatives; Neoplasms/drug therapy; Vitamin B 12/administration & dosage; Adult; Aged; Alanine Transaminase/blood; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacokinetics; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamates/adverse effects; Glutamates/pharmacokinetics; Guanine/administration & dosage; Guanine/adverse effects; Guanine/pharmacokinetics; Humans; Infusions, Intravenous; Japan; Male; Maximum Tolerated Dose; Middle Aged; Neutropenia/chemically induced; Pemetrexed; Safety; Treatment Outcome

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Full text: 1 Database: MEDLINE Main subject: Vitamin B 12 / Folic Acid / Glutamates / Guanine / Neoplasms / Antineoplastic Agents Type of study: Clinical_trials Country/Region as subject: Asia Language: En Journal: Br J Cancer Year: 2006 Type: Article Affiliation country: Japan

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