Inhibition of NF-kappaB-mediated transcription and induction of apoptosis by melampolides and repandolides.

Ma, Guoyi; Khan, Shabana I; Benavides, Gloria; Schühly, Wolfgang; Fischer, Nikolaus H; Khan, Ikhlas A; Pasco, David S

Ma, Guoyi; Khan, Shabana I; Benavides, Gloria; Schühly, Wolfgang; Fischer, Nikolaus H; Khan, Ikhlas A; Pasco, David S.

Affiliation

Ma G; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

Cancer Chemother Pharmacol ; 60(1): 35-43, 2007 Jun.

Article in En | MEDLINE | ID: mdl-17149609

Subject(s)

Apoptosis/drug effects; NF-kappa B/antagonists & inhibitors; Sesquiterpenes/pharmacology; Transcription, Genetic/drug effects; Asteraceae/chemistry; Cell Cycle/drug effects; Cell Line; Cell Line, Tumor; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Cyclooxygenase 2 Inhibitors/chemistry; Cyclooxygenase 2 Inhibitors/isolation & purification; Cyclooxygenase 2 Inhibitors/pharmacology; Dose-Response Relationship, Drug; G2 Phase/drug effects; HL-60 Cells; Humans; Inhibitory Concentration 50; Lactones/chemistry; Lactones/isolation & purification; Lactones/pharmacology; Luciferases/genetics; Luciferases/metabolism; Macrophages/drug effects; Macrophages/metabolism; Microscopy, Fluorescence; Molecular Structure; NF-kappa B/genetics; NF-kappa B/metabolism; Plant Extracts/chemistry; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Sesquiterpenes/chemistry; Sesquiterpenes/isolation & purification; Sp1 Transcription Factor/metabolism; Tetradecanoylphorbol Acetate/pharmacology

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Database: MEDLINE Main subject: Sesquiterpenes / Transcription, Genetic / NF-kappa B / Apoptosis Language: En Journal: Cancer Chemother Pharmacol Year: 2007 Type: Article Affiliation country: United States

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