Reduction of corticostriatal glutamatergic fibers in basic fibroblast growth factor deficient mice is associated with hyperactivity and enhanced dopaminergic transmission.

Fadda, Paola; Bedogni, Francesco; Fresu, Alessandra; Collu, Maria; Racagni, Giorgio; Riva, Marco A

Fadda, Paola; Bedogni, Francesco; Fresu, Alessandra; Collu, Maria; Racagni, Giorgio; Riva, Marco A.

Affiliation

Fadda P; Department of Neuroscience B.B. Brodie, Center for Excellence in Neurobiology of Dependence, University of Cagliari, Cittadella Universitaria, Monserrato, Italy.

Biol Psychiatry ; 62(3): 235-42, 2007 Aug 01.

Article in En | MEDLINE | ID: mdl-17161387

Subject(s)

Dopamine/metabolism; Fibroblast Growth Factor 2/physiology; Frontal Lobe/metabolism; Motor Activity/physiology; Neostriatum/metabolism; Neural Pathways/metabolism; Actins/genetics; Actins/metabolism; Analysis of Variance; Animals; Apomorphine/pharmacology; Cocaine/pharmacology; Dextroamphetamine/pharmacology; Dopamine Agents/pharmacology; Excitatory Amino Acid Transporter 3/genetics; Excitatory Amino Acid Transporter 3/metabolism; Exploratory Behavior/drug effects; Exploratory Behavior/physiology; Fibroblast Growth Factor 2/deficiency; Frontal Lobe/cytology; Frontal Lobe/drug effects; Glutamic Acid/metabolism; Hyperkinesis/metabolism; Mice; Mice, Knockout; Motor Activity/drug effects; Neostriatum/drug effects; Nerve Fibers/metabolism; Presynaptic Terminals/drug effects; Presynaptic Terminals/metabolism; RNA, Messenger/analysis; Synaptic Transmission/physiology; Vesicular Glutamate Transport Protein 1/genetics; Vesicular Glutamate Transport Protein 1/metabolism

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Database: MEDLINE Main subject: Dopamine / Fibroblast Growth Factor 2 / Neostriatum / Frontal Lobe / Motor Activity / Neural Pathways Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Biol Psychiatry Year: 2007 Type: Article Affiliation country: Italy

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