In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.

Li, Jin; Bronk, Brian S; Dirlam, John P; Blize, Alan E; Bertinato, Peter; Jaynes, Burton H; Hickman, Anne; Miskell, Christine; Pillai, Usha A; Tibbitts, Jay S; Haven, Michelle L; Kolosko, Nicole L; Barry, Chris J; Manion, Tara B

Li, Jin; Bronk, Brian S; Dirlam, John P; Blize, Alan E; Bertinato, Peter; Jaynes, Burton H; Hickman, Anne; Miskell, Christine; Pillai, Usha A; Tibbitts, Jay S; Haven, Michelle L; Kolosko, Nicole L; Barry, Chris J; Manion, Tara B.

Affiliation

Li J; Pfizer Inc., Groton, CT 06340, USA. jin.li@pfizer.com

Bioorg Med Chem Lett ; 17(7): 1996-9, 2007 Apr 01.

Article in En | MEDLINE | ID: mdl-17276061

Subject(s)

Carbamates/chemical synthesis; Carboxylic Acids/chemistry; Carboxylic Acids/chemical synthesis; Carrier Proteins/antagonists & inhibitors; Chemistry, Pharmaceutical/methods; Indoles/chemical synthesis; Obesity/drug therapy; Animals; Carbamates/chemistry; Carbamates/pharmacology; Carboxylic Acids/pharmacology; Dogs; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles/chemistry; Indoles/pharmacology; Inhibitory Concentration 50; Models, Chemical; Molecular Conformation; Rats

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Database: MEDLINE Main subject: Carbamates / Carboxylic Acids / Carrier Proteins / Chemistry, Pharmaceutical / Indoles / Obesity Language: En Journal: Bioorg Med Chem Lett Year: 2007 Type: Article Affiliation country: United States

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