Active site of epoxide hydrolases revisited: a noncanonical residue in potato StEH1 promotes both formation and breakdown of the alkylenzyme intermediate.

Thomaeus, Ann; Carlsson, Jens; Aqvist, Johan; Widersten, Mikael

Thomaeus, Ann; Carlsson, Jens; Aqvist, Johan; Widersten, Mikael.

Affiliation

Thomaeus A; Department of Biochemistry and Organic Chemistry, Box 576, Uppsala University, BMC, SE-751 23 Uppsala, Sweden.

Biochemistry ; 46(9): 2466-79, 2007 Mar 06.

Article in En | MEDLINE | ID: mdl-17284015

Subject(s)

Epoxide Hydrolases/metabolism; Solanum tuberosum/enzymology; Amino Acid Sequence; Binding Sites; Epoxide Hydrolases/chemistry; Epoxide Hydrolases/genetics; Epoxide Hydrolases/isolation & purification; Glutamic Acid/chemistry; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Sequence Homology, Amino Acid

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Database: MEDLINE Main subject: Solanum tuberosum / Epoxide Hydrolases Type of study: Prognostic_studies Language: En Journal: Biochemistry Year: 2007 Type: Article Affiliation country: Sweden

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