Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases.

Gayathri, B; Manjula, N; Vinaykumar, K S; Lakshmi, B S; Balakrishnan, A

Gayathri, B; Manjula, N; Vinaykumar, K S; Lakshmi, B S; Balakrishnan, A.

Affiliation

Gayathri B; Centre for Biotechnology, Anna University, Chennai, India.

Int Immunopharmacol ; 7(4): 473-82, 2007 Apr.

Article in En | MEDLINE | ID: mdl-17321470

Subject(s)

Anti-Inflammatory Agents/pharmacology; Boswellia/chemistry; Macrophages/drug effects; Animals; Cell Line; Cell Proliferation/drug effects; Cyclooxygenase 2/metabolism; Cyclooxygenase 2 Inhibitors/pharmacology; Cytokines/antagonists & inhibitors; Cytokines/genetics; Cytokines/metabolism; Humans; Lipopolysaccharides; Macrophages/metabolism; Mice; Mitogen-Activated Protein Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinases/metabolism; Nitric Oxide/antagonists & inhibitors; Nitric Oxide/metabolism; Plant Extracts/pharmacology; Proto-Oncogene Proteins c-fos/antagonists & inhibitors; Proto-Oncogene Proteins c-fos/metabolism; Proto-Oncogene Proteins c-jun/antagonists & inhibitors; Proto-Oncogene Proteins c-jun/metabolism; RNA, Messenger/metabolism

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Database: MEDLINE Main subject: Boswellia / Macrophages / Anti-Inflammatory Agents Language: En Journal: Int Immunopharmacol Year: 2007 Type: Article Affiliation country: India

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