Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha.

Ebel, Wolfgang; Routhier, Eric L; Foley, Brian; Jacob, Sara; McDonough, Jennifer M; Patel, Rina K; Turchin, Howard A; Chao, Qimin; Kline, J Bradford; Old, Lloyd J; Phillips, Martin D; Nicolaides, Nicholas C; Sass, Philip M; Grasso, Luigi

Ebel, Wolfgang; Routhier, Eric L; Foley, Brian; Jacob, Sara; McDonough, Jennifer M; Patel, Rina K; Turchin, Howard A; Chao, Qimin; Kline, J Bradford; Old, Lloyd J; Phillips, Martin D; Nicolaides, Nicholas C; Sass, Philip M; Grasso, Luigi.

Affiliation

Ebel W; Morphotek Inc., 210 Welsh Pool Road, Exton, PA, USA.

Cancer Immun ; 7: 6, 2007 Mar 09.

Article in En | MEDLINE | ID: mdl-17346028

Subject(s)

Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal/therapeutic use; Carrier Proteins/antagonists & inhibitors; Carrier Proteins/immunology; Immunotherapy/methods; Ovarian Neoplasms/drug therapy; Receptors, Cell Surface/antagonists & inhibitors; Receptors, Cell Surface/immunology; Animals; Antibodies, Monoclonal/adverse effects; Antibodies, Monoclonal/pharmacokinetics; Antibody-Dependent Cell Cytotoxicity/drug effects; Antibody-Dependent Cell Cytotoxicity/immunology; CHO Cells; Cell Line, Tumor; Cell Proliferation/drug effects; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; Female; Folate Receptors, GPI-Anchored; Humans; Kinetics; Mice; Mice, Nude; Neoplasm Proteins/immunology; Primates/immunology; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Ovarian Neoplasms / Carrier Proteins / Receptors, Cell Surface / Immunotherapy / Antibodies, Monoclonal Language: En Journal: Cancer Immun Year: 2007 Type: Article Affiliation country: United States

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