Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays.

Nadanaciva, Sashi; Bernal, Autumn; Aggeler, Robert; Capaldi, Roderick; Will, Yvonne

Nadanaciva, Sashi; Bernal, Autumn; Aggeler, Robert; Capaldi, Roderick; Will, Yvonne.

Affiliation

Nadanaciva S; MitoSciences Inc, 1850 Millrace Drive, Eugene, OR 97403, USA. snadanaciva@mitosciences.com

Toxicol In Vitro ; 21(5): 902-11, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17346924

Subject(s)

Mitochondria, Heart/drug effects; Oxidative Phosphorylation/drug effects; Uncoupling Agents/toxicity; Animals; Antibodies, Monoclonal; Cattle; Drug Evaluation, Preclinical/methods; Electron Transport Complex I/antagonists & inhibitors; Electron Transport Complex I/metabolism; Electron Transport Complex II/antagonists & inhibitors; Electron Transport Complex II/metabolism; Enzyme Inhibitors/toxicity; Immunochemistry; In Vitro Techniques; Oligomycins/toxicity; Potassium Cyanide/toxicity; Proton-Translocating ATPases/antagonists & inhibitors; Proton-Translocating ATPases/metabolism; Rotenone/toxicity; Succinate Cytochrome c Oxidoreductase/antagonists & inhibitors; Succinate Cytochrome c Oxidoreductase/metabolism; Thenoyltrifluoroacetone/toxicity

Search on Google

Add to My VHL

XML

PubMed Links

Database: MEDLINE Main subject: Oxidative Phosphorylation / Uncoupling Agents / Mitochondria, Heart Type of study: Diagnostic_studies Language: En Journal: Toxicol In Vitro Year: 2007 Type: Article Affiliation country: United States

Search on Google

Add to My VHL

XML

PubMed Links