Adrenomedullin 2 (AM2)/intermedin is a more potent activator of hypothalamic oxytocin-secreting neurons than AM possibly through an unidentified receptor in rats.

Hashimoto, Hirofumi; Hyodo, Susumu; Kawasaki, Makoto; Shibata, Minori; Saito, Takeshi; Suzuki, Hitoshi; Otsubo, Hiroki; Yokoyama, Toru; Fujihara, Hiroaki; Higuchi, Takashi; Takei, Yoshio; Ueta, Yoichi

Hashimoto, Hirofumi; Hyodo, Susumu; Kawasaki, Makoto; Shibata, Minori; Saito, Takeshi; Suzuki, Hitoshi; Otsubo, Hiroki; Yokoyama, Toru; Fujihara, Hiroaki; Higuchi, Takashi; Takei, Yoshio; Ueta, Yoichi.

Affiliation

Hashimoto H; Department of Physiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

Peptides ; 28(5): 1104-12, 2007 May.

Article in En | MEDLINE | ID: mdl-17386959

Subject(s)

Adrenomedullin/pharmacology; Hypothalamus/drug effects; Neurons/drug effects; Neuropeptides/pharmacology; Oxytocin/metabolism; Adrenomedullin/administration & dosage; Adrenomedullin/chemistry; Animals; Calcitonin Gene-Related Peptide/administration & dosage; Calcitonin Gene-Related Peptide/pharmacology; Gene Expression/drug effects; Genes, fos/genetics; Hypothalamus/cytology; Hypothalamus/metabolism; In Situ Hybridization; Male; Neurons/cytology; Neurons/metabolism; Neuropeptides/administration & dosage; Neuropeptides/chemistry; Oxytocin/blood; Paraventricular Hypothalamic Nucleus/drug effects; Paraventricular Hypothalamic Nucleus/metabolism; Peptide Fragments/administration & dosage; Peptide Fragments/pharmacology; RNA, Messenger/genetics; RNA, Messenger/metabolism; Rats; Rats, Wistar; Receptors, Adrenomedullin; Receptors, Peptide/antagonists & inhibitors; Supraoptic Nucleus/drug effects; Supraoptic Nucleus/metabolism; Sympathetic Nervous System/drug effects; Sympathetic Nervous System/physiology; Time Factors

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Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Neuropeptides / Oxytocin / Adrenomedullin / Hypothalamus / Neurons Language: En Journal: Peptides Year: 2007 Type: Article Affiliation country: Japan

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