Effect of bisphosphonates on bone mineral density after renal transplantation as assessed by bone mineral densitometry.
Transplant Proc
; 39(3): 750-2, 2007 Apr.
Article
in En
| MEDLINE
| ID: mdl-17445589
ABSTRACT
INTRODUCTION:
Steroid-induced osteoporosis is a major problem after organ transplantation. There is considerable evidence that bisphosphonates are effective in decreasing osteoporosis.AIM:
This prospective study was carried out to see the effects of bisphosphonates on bone mineral density (BMD) after successful renal transplantation. MATERIAL ANDMETHODS:
Fifty consecutive patients of successful renal transplantation were randomized into two groups. Group A (n = 27) received 35 mg/wk of Alendronate for 6 months after transplantation. Group B (n = 23) did not receive Alendronate and served as a control. Both groups underwent a pretransplant baseline dual-energy X-ray absorptiometry (DEXA) scan of their hips and lumber spines. Both groups received oral calcium and vitamin D supplement. Both groups were matched for the regimen and dose of immunosuppressive drugs. BMD was measured at 3 months and 6 months after transplantation.RESULTS:
Both groups showed a decline in BMD in early months posttransplantation. However, the 6-month DEXA scans showed a significant rise in BMD in group A as compared to group B.CONCLUSION:
Bisphosphonates appear to have a beneficial effect on steroid-induced bone loss.
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Database:
MEDLINE
Main subject:
Bone Density
/
Kidney Transplantation
/
Alendronate
/
Bone Density Conservation Agents
Type of study:
Clinical_trials
/
Observational_studies
Language:
En
Journal:
Transplant Proc
Year:
2007
Type:
Article
Affiliation country:
India