Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells.

Arnold, Julia T; Liu, Xunxian; Allen, Jeffrey D; Le, Hanh; McFann, Kimberly K; Blackman, Marc R

Arnold, Julia T; Liu, Xunxian; Allen, Jeffrey D; Le, Hanh; McFann, Kimberly K; Blackman, Marc R.

Affiliation

Arnold JT; Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892-0933, USA. jarnold@mail.nih.gov

Prostate ; 67(11): 1152-62, 2007 Aug 01.

Article in En | MEDLINE | ID: mdl-17503469

Subject(s)

Androgen Receptor Antagonists; Dehydroepiandrosterone/pharmacology; Estrogen Receptor beta/antagonists & inhibitors; Prostate-Specific Antigen/biosynthesis; Prostatic Neoplasms/pathology; Testosterone/analogs & derivatives; Androgen Antagonists/pharmacology; Anilides/pharmacology; Cell Division/drug effects; Cell Line, Tumor; Estradiol/analogs & derivatives; Estradiol/pharmacology; Estrogen Antagonists/pharmacology; Estrogen Receptor beta/physiology; Fulvestrant; Gene Expression/drug effects; Humans; Male; Nitriles/pharmacology; Prostate-Specific Antigen/genetics; Prostate-Specific Antigen/metabolism; Prostatic Neoplasms/metabolism; RNA, Messenger/analysis; RNA, Small Interfering/pharmacology; Receptors, Androgen/physiology; Testosterone/pharmacology; Tosyl Compounds/pharmacology

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Database: MEDLINE Main subject: Prostatic Neoplasms / Testosterone / Prostate-Specific Antigen / Dehydroepiandrosterone / Estrogen Receptor beta / Androgen Receptor Antagonists Language: En Journal: Prostate Year: 2007 Type: Article Affiliation country: United States

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