Quantitative imaging and sigmoidoscopy to assess distribution of rectal microbicide surrogates.

Hendrix, C W; Fuchs, E J; Macura, K J; Lee, L A; Parsons, T L; Bakshi, R P; Khan, W A; Guidos, A; Leal, J P; Wahl, R

Hendrix, C W; Fuchs, E J; Macura, K J; Lee, L A; Parsons, T L; Bakshi, R P; Khan, W A; Guidos, A; Leal, J P; Wahl, R.

Affiliation

Hendrix CW; Department of Medicine, Division of Clinical Pharmacology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA. chendrix@jhmi.edu

Clin Pharmacol Ther ; 83(1): 97-105, 2008 Jan.

Article in En | MEDLINE | ID: mdl-17507921

Subject(s)

Anti-HIV Agents/metabolism; Anti-Infective Agents, Local/metabolism; Cellulose/analogs & derivatives; Diagnostic Imaging/methods; HIV Infections/metabolism; Rectum/metabolism; Sigmoidoscopy; Administration, Rectal; Adult; Anti-HIV Agents/administration & dosage; Anti-HIV Agents/therapeutic use; Anti-Infective Agents, Local/administration & dosage; Anti-Infective Agents, Local/therapeutic use; Cellulose/administration & dosage; Cellulose/metabolism; Cellulose/therapeutic use; Coitus; Contrast Media; Ejaculation; Enema; Feasibility Studies; Gadolinium DTPA/administration & dosage; Gels; HIV Infections/pathology; HIV Infections/prevention & control; Humans; Magnetic Resonance Imaging; Pilot Projects; Radiopharmaceuticals/administration & dosage; Rectum/pathology; Semen/metabolism; Technetium Tc 99m Sulfur Colloid/administration & dosage; Time Factors; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Unsafe Sex

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Database: MEDLINE Main subject: Rectum / Diagnostic Imaging / HIV Infections / Cellulose / Sigmoidoscopy / Anti-HIV Agents / Anti-Infective Agents, Local Type of study: Diagnostic_studies / Evaluation_studies / Prognostic_studies Language: En Journal: Clin Pharmacol Ther Year: 2008 Type: Article Affiliation country: United States

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