HMCO5, herbal extract, inhibits NF-kappaB expression in lipopolysaccharide treated macrophages and reduces atherosclerotic lesions in cholesterol fed mice.

Kim, Ki Mo; Choi, Jin Yong; Yoo, Si-Eun; Park, Mi Young; Lee, Bok-Soo; Ko, Young Hye; Sung, Sang Hyun; Shin, Heung-Mook; Park, Jeong Euy

HMCO5, herbal extract, inhibits NF-kappaB expression in lipopolysaccharide treated macrophages and reduces atherosclerotic lesions in cholesterol fed mice.

Kim, Ki Mo; Choi, Jin Yong; Yoo, Si-Eun; Park, Mi Young; Lee, Bok-Soo; Ko, Young Hye; Sung, Sang Hyun; Shin, Heung-Mook; Park, Jeong Euy.

Affiliation

Kim KM; Division of Cardiology, Samsung Medical Center & Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, South Korea.

J Ethnopharmacol ; 114(3): 316-24, 2007 Dec 03.

Article in En | MEDLINE | ID: mdl-17931811

Subject(s)

Atherosclerosis/drug therapy; Macrophages/drug effects; NF-kappa B/antagonists & inhibitors; Plant Extracts/pharmacology; Active Transport, Cell Nucleus/drug effects; Animals; Apolipoproteins E/physiology; Cholesterol, Dietary/administration & dosage; Cyclooxygenase 2 Inhibitors/pharmacology; Interleukin-1beta/antagonists & inhibitors; Lipopolysaccharides/pharmacology; Macrophages/metabolism; Mice; Muscle, Smooth, Vascular/drug effects; NADPH Oxidases/antagonists & inhibitors; Nitric Oxide Synthase Type II/antagonists & inhibitors; Plant Extracts/therapeutic use; Tumor Necrosis Factor-alpha/antagonists & inhibitors

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Database: MEDLINE Main subject: Plant Extracts / NF-kappa B / Atherosclerosis / Macrophages Language: En Journal: J Ethnopharmacol Year: 2007 Type: Article Affiliation country: South Korea

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