Anemia, Sickle Cell/drug therapy; Cell Communication/drug effects; Erythrocytes, Abnormal/metabolism; Immunoglobulins, Intravenous/pharmacology; Immunologic Factors/pharmacology; Neutrophils/metabolism; Vascular Diseases/drug therapy; Anemia, Sickle Cell/complications; Anemia, Sickle Cell/metabolism; Anemia, Sickle Cell/pathology; Animals; Cell Adhesion/drug effects; Disease Models, Animal; Drug Evaluation, Preclinical; Erythrocytes, Abnormal/pathology; Humans; Immunoglobulins, Intravenous/therapeutic use; Leukocyte Rolling/drug effects; Mice; Mice, Transgenic; Microcirculation/metabolism; Microcirculation/pathology; Microscopy, Fluorescence; Microscopy, Video; Neutrophils/pathology; Vascular Diseases/etiology; Vascular Diseases/metabolism; Vascular Diseases/pathology; Venules/metabolism; Venules/pathology