SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy.

Kaminski, Rafal M; Matagne, Alain; Leclercq, Karine; Gillard, Michel; Michel, Philippe; Kenda, Benoit; Talaga, Patrice; Klitgaard, Henrik

Kaminski, Rafal M; Matagne, Alain; Leclercq, Karine; Gillard, Michel; Michel, Philippe; Kenda, Benoit; Talaga, Patrice; Klitgaard, Henrik.

Affiliation

Kaminski RM; CNS Research, UCB PHARMA SA, Chemin du Foriest R9, Braine-l'Alleud, Belgium. rafal.kaminski@ucb-group.com

Neuropharmacology ; 54(4): 715-20, 2008 Mar.

Article in En | MEDLINE | ID: mdl-18207204

Subject(s)

Epilepsies, Partial/metabolism; Epilepsy, Generalized/metabolism; Membrane Glycoproteins/metabolism; Nerve Tissue Proteins/metabolism; Acoustic Stimulation/adverse effects; Animals; Anticonvulsants/therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsies, Partial/diet therapy; Epilepsies, Partial/etiology; Epilepsy, Generalized/drug therapy; Epilepsy, Generalized/etiology; Female; Inhibitory Concentration 50; Ligands; Male; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/genetics; Mice; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Protein Binding/drug effects

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Full text: 1 Database: MEDLINE Main subject: Membrane Glycoproteins / Epilepsies, Partial / Epilepsy, Generalized / Nerve Tissue Proteins Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Neuropharmacology Year: 2008 Type: Article Affiliation country: Belgium

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