Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.

Bembenek, Scott D; Keith, John M; Letavic, Michael A; Apodaca, Richard; Barbier, Ann J; Dvorak, Lisa; Aluisio, Leah; Miller, Kirsten L; Lovenberg, Timothy W; Carruthers, Nicholas I

Bembenek, Scott D; Keith, John M; Letavic, Michael A; Apodaca, Richard; Barbier, Ann J; Dvorak, Lisa; Aluisio, Leah; Miller, Kirsten L; Lovenberg, Timothy W; Carruthers, Nicholas I.

Affiliation

Bembenek SD; Johnson & Johnson Pharmaceutical Research and Development, L.L.C. 3210 Merryfield Row, San Diego, CA 92121, USA. sbembene@prdus.jnj.com

Bioorg Med Chem ; 16(6): 2968-73, 2008 Mar 15.

Article in En | MEDLINE | ID: mdl-18249544

Subject(s)

Cholinesterase Inhibitors/chemistry; Histamine H3 Antagonists/chemistry; Models, Molecular; Alzheimer Disease/drug therapy; Drug Evaluation, Preclinical/methods; Humans; Quantitative Structure-Activity Relationship

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Full text: 1 Database: MEDLINE Main subject: Models, Molecular / Cholinesterase Inhibitors / Histamine H3 Antagonists Type of study: Diagnostic_studies / Guideline Language: En Journal: Bioorg Med Chem Year: 2008 Type: Article Affiliation country: United States

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