Naturally occurring small-molecule inhibitors of hedgehog/GLI-mediated transcription.

Hosoya, Takahiro; Arai, Midori A; Koyano, Takashi; Kowithayakorn, Thaworn; Ishibashi, Masami

Hosoya, Takahiro; Arai, Midori A; Koyano, Takashi; Kowithayakorn, Thaworn; Ishibashi, Masami.

Affiliation

Hosoya T; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan.

Chembiochem ; 9(7): 1082-92, 2008 May 05.

Article in En | MEDLINE | ID: mdl-18357592

Subject(s)

Biological Products/chemistry; Biological Products/pharmacology; Hedgehog Proteins/antagonists & inhibitors; Oncogene Proteins/antagonists & inhibitors; Small Molecule Libraries/pharmacology; Trans-Activators/antagonists & inhibitors; Transcription, Genetic/drug effects; Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic/drug effects; Hedgehog Proteins/metabolism; Humans; Inhibitory Concentration 50; Oncogene Proteins/metabolism; Plant Extracts/chemistry; Plant Extracts/pharmacology; Signal Transduction/drug effects; Trans-Activators/metabolism; Transcriptional Activation/drug effects; Zinc Finger Protein GLI1

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Full text: 1 Database: MEDLINE Main subject: Transcription, Genetic / Biological Products / Trans-Activators / Oncogene Proteins / Hedgehog Proteins / Small Molecule Libraries Type of study: Prognostic_studies Language: En Journal: Chembiochem Year: 2008 Type: Article Affiliation country: Japan

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