Solid-phase combinatorial synthesis of a lysyl-tRNA synthetase (LysRS) inhibitory library.

Farrera-Sinfreu, Josep; Español, Yaiza; Geslain, Renaud; Guitart, Tanit; Albericio, Fernando; Ribas de Pouplana, Lluís; Royo, Miriam

Farrera-Sinfreu, Josep; Español, Yaiza; Geslain, Renaud; Guitart, Tanit; Albericio, Fernando; Ribas de Pouplana, Lluís; Royo, Miriam.

Affiliation

Farrera-Sinfreu J; Institute for Research in Biomedicine and Combinatorial Chemistry Unit, Barcelona Science Park, University of Barcelona, Josep Samitier 1, 08028-Barcelona, Spain.

J Comb Chem ; 10(3): 391-400, 2008.

Article in En | MEDLINE | ID: mdl-18426239

Subject(s)

Antiprotozoal Agents/chemical synthesis; Combinatorial Chemistry Techniques; Lysine-tRNA Ligase/antagonists & inhibitors; Proline/chemical synthesis; Aminoacylation/drug effects; Animals; Antiprotozoal Agents/pharmacology; Chromatography, High Pressure Liquid/methods; Drug Evaluation, Preclinical; Lysine-tRNA Ligase/chemistry; Lysine-tRNA Ligase/isolation & purification; Molecular Conformation; Proline/analogs & derivatives; Proline/pharmacology; Stereoisomerism; Trypanosoma brucei brucei/enzymology

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Full text: 1 Database: MEDLINE Main subject: Proline / Combinatorial Chemistry Techniques / Lysine-tRNA Ligase / Antiprotozoal Agents Language: En Journal: J Comb Chem Year: 2008 Type: Article Affiliation country: Spain

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