Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors.

Minami, Hironobu; Kawada, Kenji; Ebi, Hiromichi; Kitagawa, Koichi; Kim, Yon-il; Araki, Kazuhiro; Mukai, Hirofumi; Tahara, Makoto; Nakajima, Hikaru; Nakajima, Keiko

Minami, Hironobu; Kawada, Kenji; Ebi, Hiromichi; Kitagawa, Koichi; Kim, Yon-il; Araki, Kazuhiro; Mukai, Hirofumi; Tahara, Makoto; Nakajima, Hikaru; Nakajima, Keiko.

Affiliation

Minami H; Oncology/Hematology, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan. hminami@med.kobe-u.ac.jp

Cancer Sci ; 99(7): 1492-8, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18477034

Subject(s)

Antineoplastic Agents/therapeutic use; Benzenesulfonates/therapeutic use; Neoplasms/drug therapy; Protein Kinase Inhibitors/therapeutic use; Pyridines/therapeutic use; Adult; Aged; Benzenesulfonates/adverse effects; Benzenesulfonates/pharmacokinetics; Extracellular Signal-Regulated MAP Kinases/metabolism; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Niacinamide/analogs & derivatives; Phenylurea Compounds; Phosphorylation; Positron-Emission Tomography; Pyridines/adverse effects; Pyridines/pharmacokinetics; Sorafenib

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Pyridines / Benzenesulfonates / Protein Kinase Inhibitors / Neoplasms / Antineoplastic Agents Language: En Journal: Cancer Sci Year: 2008 Type: Article Affiliation country: Japan

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google