Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide.

Coppola, Teresa; Varra, Michela; Oliviero, Giorgia; Galeone, Aldo; D'Isa, Giuliana; Mayol, Luciano; Morelli, Elena; Bucci, Maria-Rosaria; Vellecco, Valentina; Cirino, Giuseppe; Borbone, Nicola

Coppola, Teresa; Varra, Michela; Oliviero, Giorgia; Galeone, Aldo; D'Isa, Giuliana; Mayol, Luciano; Morelli, Elena; Bucci, Maria-Rosaria; Vellecco, Valentina; Cirino, Giuseppe; Borbone, Nicola.

Affiliation

Coppola T; Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, via D. Montesano 49, 80131 Napoli, Italy.

Bioorg Med Chem ; 16(17): 8244-53, 2008 Sep 01.

Article in En | MEDLINE | ID: mdl-18752966

Subject(s)

Aptamers, Nucleotide/chemical synthesis; Aptamers, Nucleotide/pharmacology; Nucleotides/chemical synthesis; Nucleotides/pharmacology; Thrombin/chemical synthesis; Thrombin/pharmacology; Aptamers, Nucleotide/chemistry; Blood Coagulation/drug effects; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibrinogen/drug effects; Fibrinogen/isolation & purification; Humans; Magnetic Resonance Spectroscopy/methods; Magnetic Resonance Spectroscopy/standards; Molecular Structure; Nucleotides/chemistry; Reference Standards; Stereoisomerism; Structure-Activity Relationship; Temperature; Thrombin/chemistry; Time Factors

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Full text: 1 Database: MEDLINE Main subject: Thrombin / Aptamers, Nucleotide / Nucleotides Language: En Journal: Bioorg Med Chem Year: 2008 Type: Article Affiliation country: Italy

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