Indoles/pharmacology; Isoenzymes/antagonists & inhibitors; Nitriles/pharmacology; Protein Kinase C/antagonists & inhibitors; Protein Kinase Inhibitors/pharmacology; Pyridines/pharmacology; Animals; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indoles/chemical synthesis; Indoles/chemistry; Interleukin-2/antagonists & inhibitors; Interleukin-2/biosynthesis; Isoenzymes/deficiency; Isoenzymes/drug effects; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Molecular Structure; Nitriles/chemical synthesis; Nitriles/chemistry; Protein Kinase C/deficiency; Protein Kinase C/drug effects; Protein Kinase C-theta; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/chemistry; Pyridines/chemical synthesis; Pyridines/chemistry; Spleen/cytology; Spleen/drug effects; Spleen/immunology; Stereoisomerism; Structure-Activity Relationship; T-Lymphocytes/drug effects; T-Lymphocytes/immunology