Immunodrugs: therapeutic VLP-based vaccines for chronic diseases.
Annu Rev Pharmacol Toxicol
; 49: 303-26, 2009.
Article
in En
| MEDLINE
| ID: mdl-18851703
ABSTRACT
Worldwide, the prevalence of noncommunicable chronic diseases is increasing. The use of vaccines to induce autoantibodies that neutralize disease-related proteins offers a means to effectively and affordably treat such diseases. Twenty vaccines designed to induce therapeutic autoantibodies were clinically tested in the past 12 years. Immunodrugs are therapeutic vaccines comprising virus-like particles (VLPs) covalently conjugated with self-antigens that induce neutralizing autoantibody responses. Four such VLP-based vaccines have been clinically tested and one has achieved proof of principle a reduction of blood pressure in hypertensive patients. To facilitate preliminary clinical testing, novel nonclinical study programs have been developed. Safety study designs have considered the underlying B and T cell immunology and have examined potential toxicities of vaccine components and primary and secondary pharmacodynamic action of the vaccines.
Full text:
1
Database:
MEDLINE
Main subject:
Virion
/
Vaccines
/
Chronic Disease
/
Immunotherapy
Type of study:
Risk_factors_studies
Language:
En
Journal:
Annu Rev Pharmacol Toxicol
Year:
2009
Type:
Article
Affiliation country:
Switzerland