Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells.

Gundimeda, Usha; Schiffman, Jason Eric; Chhabra, Divya; Wong, Jourdan; Wu, Adela; Gopalakrishna, Rayudu

Gundimeda, Usha; Schiffman, Jason Eric; Chhabra, Divya; Wong, Jourdan; Wu, Adela; Gopalakrishna, Rayudu.

Affiliation

Gundimeda U; Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.

J Biol Chem ; 283(50): 34519-31, 2008 Dec 12.

Article in En | MEDLINE | ID: mdl-18922790

Subject(s)

Apoptosis; Organoselenium Compounds/metabolism; Prostatic Neoplasms/enzymology; Protein Kinase C/metabolism; Selenium/pharmacology; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Cell Survival/drug effects; Drug Resistance, Neoplasm; Humans; Isoenzymes/chemistry; Male; Oxygen/chemistry; Prostatic Neoplasms/metabolism; Protein Kinase C/chemistry; RNA, Small Interfering/metabolism

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Full text: 1 Database: MEDLINE Main subject: Prostatic Neoplasms / Selenium / Protein Kinase C / Organoselenium Compounds / Apoptosis Language: En Journal: J Biol Chem Year: 2008 Type: Article Affiliation country: United States

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