Sympathoexcitation by oxidative stress in the brain mediates arterial pressure elevation in obesity-induced hypertension.

Nagae, Ai; Fujita, Megumi; Kawarazaki, Hiroo; Matsui, Hiromitsu; Ando, Katsuyuki; Fujita, Toshiro

Nagae, Ai; Fujita, Megumi; Kawarazaki, Hiroo; Matsui, Hiromitsu; Ando, Katsuyuki; Fujita, Toshiro.

Affiliation

Nagae A; Department of Nephrology and Endocrinology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Circulation ; 119(7): 978-86, 2009 Feb 24.

Article in En | MEDLINE | ID: mdl-19204299

Subject(s)

Brain/metabolism; Hypertension/etiology; Obesity/complications; Oxidative Stress; Sympathetic Nervous System/physiology; Acetophenones/pharmacology; Animals; Blood Pressure/drug effects; Cyclic N-Oxides/pharmacology; Heart Rate/drug effects; Hexamethonium/pharmacology; Hypothalamus/metabolism; Intra-Abdominal Fat/metabolism; Kidney/innervation; Male; NADPH Oxidases; Norepinephrine/urine; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides/metabolism

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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Sympathetic Nervous System / Brain / Oxidative Stress / Hypertension / Obesity Type of study: Risk_factors_studies Language: En Journal: Circulation Year: 2009 Type: Article Affiliation country: Japan

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