Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.

Kijima, Mika; Iwata, Akiko; Maekawa, Yoichi; Uehara, Hisanori; Izumi, Keisuke; Kitamura, Akiko; Yagita, Hideo; Chiba, Shigeru; Shiota, Hiroshi; Yasutomo, Koji

Kijima, Mika; Iwata, Akiko; Maekawa, Yoichi; Uehara, Hisanori; Izumi, Keisuke; Kitamura, Akiko; Yagita, Hideo; Chiba, Shigeru; Shiota, Hiroshi; Yasutomo, Koji.

Affiliation

Kijima M; Department of Immunology and Parasitology, University of Tokushima Graduate School, Tokushima, Japan.

J Immunol ; 182(6): 3566-72, 2009 Mar 15.

Article in En | MEDLINE | ID: mdl-19265135

Subject(s)

Arthritis, Experimental/immunology; Arthritis, Experimental/therapy; CD8-Positive T-Lymphocytes/immunology; Calcium-Binding Proteins/physiology; Calcium-Binding Proteins/therapeutic use; Growth Inhibitors/therapeutic use; Intercellular Signaling Peptides and Proteins/physiology; Intercellular Signaling Peptides and Proteins/therapeutic use; Lymphocyte Activation/immunology; Membrane Proteins/physiology; Membrane Proteins/therapeutic use; Signal Transduction/immunology; Animals; Arthritis, Experimental/pathology; CD8-Positive T-Lymphocytes/pathology; Calcium-Binding Proteins/administration & dosage; Calcium-Binding Proteins/genetics; Cell Line; Cells, Cultured; Down-Regulation/genetics; Down-Regulation/immunology; Growth Inhibitors/administration & dosage; Growth Inhibitors/genetics; Growth Inhibitors/physiology; Humans; Intercellular Signaling Peptides and Proteins/administration & dosage; Intercellular Signaling Peptides and Proteins/genetics; Jagged-1 Protein; Jurkat Cells; Lymphocyte Activation/genetics; Lymphocyte Depletion; Male; Membrane Proteins/administration & dosage; Membrane Proteins/genetics; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Plasmids/administration & dosage; Plasmids/genetics; Plasmids/therapeutic use; Serrate-Jagged Proteins; Signal Transduction/genetics; Vaccines, DNA/administration & dosage; Vaccines, DNA/genetics; Vaccines, DNA/therapeutic use

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Full text: 1 Database: MEDLINE Main subject: Arthritis, Experimental / Calcium-Binding Proteins / Lymphocyte Activation / Signal Transduction / CD8-Positive T-Lymphocytes / Intercellular Signaling Peptides and Proteins / Growth Inhibitors / Membrane Proteins Type of study: Prognostic_studies Language: En Journal: J Immunol Year: 2009 Type: Article Affiliation country: Japan

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