Exposure to supplemental oxygen downregulates antioxidant enzymes and increases pulmonary arterial contractility in premature lambs.

Patel, Anupama; Lakshminrusimha, Satyan; Ryan, Rita M; Swartz, Daniel D; Wang, Huamei; Wynn, Karen A; Kumar, Vasanth H

Patel, Anupama; Lakshminrusimha, Satyan; Ryan, Rita M; Swartz, Daniel D; Wang, Huamei; Wynn, Karen A; Kumar, Vasanth H.

Affiliation

Patel A; Center for Developmental Biology of the Lung, Department of Pediatrics, University at Buffalo, Buffalo, NY 14222-2006, USA.

Neonatology ; 96(3): 182-92, 2009.

Article in En | MEDLINE | ID: mdl-19365144

Subject(s)

Lung/drug effects; Oxidoreductases/metabolism; Oxygen/administration & dosage; Pulmonary Artery/drug effects; Vasoconstriction/drug effects; Animals; Animals, Newborn; Catalase/metabolism; Catalase/pharmacology; Disease Models, Animal; Down-Regulation; Drug Interactions; Gestational Age; Glutathione Disulfide/blood; In Vitro Techniques; Lipid Peroxides/metabolism; Lung/enzymology; Norepinephrine/pharmacology; Oxygen/blood; Potassium Chloride/pharmacology; Pulmonary Alveoli/physiology; Pulmonary Artery/enzymology; Respiration, Artificial; Resuscitation; Sheep; Superoxide Dismutase/metabolism; Superoxide Dismutase/pharmacology; Vasoconstriction/physiology

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Full text: 1 Database: MEDLINE Main subject: Oxidoreductases / Oxygen / Pulmonary Artery / Vasoconstriction / Lung Language: En Journal: Neonatology Year: 2009 Type: Article Affiliation country: United States

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