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Long term survival in anti-Hu associated adult neuroblastoma.
Jarius, Sven; Arnold, Stephan; Linke, Rainer; Noachtar, Soheyl; Schlemmer, Marcus; Issels, Rolf; Voltz, Raymond.
Affiliation
  • Jarius S; Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
J Neurol Sci ; 284(1-2): 205-8, 2009 Sep 15.
Article in En | MEDLINE | ID: mdl-19442989
We report on a young lady suffering from adult neuroblastoma and anti-Hu associated paraneoplastic encephalomyelitis (PEM) with a tumour free survival of nine years up to now. Treatment included tumour surgery, radiation, high dose chemotherapy, and stem cell transplantation. Serological testing demonstrated a marked decline in anti-Hu antibody titres under therapy, and subsequent disappearance of the antibody 31 months after second tumour resection.
Subject(s)
Autoantibodies/immunology; Autoantigens/immunology; Autoimmune Diseases of the Nervous System/etiology; ELAV Proteins/immunology; Ganglioneuroma/complications; Neoplasms, Multiple Primary/complications; Neuroblastoma/complications; Para-Aortic Bodies/pathology; Paraneoplastic Syndromes, Nervous System/etiology; Retroperitoneal Neoplasms/complications; Survivors; Antibodies, Viral/blood; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Autoantibodies/blood; Autoimmune Diseases of the Nervous System/diagnostic imaging; Autoimmune Diseases of the Nervous System/immunology; Combined Modality Therapy; Diagnostic Errors; Female; Ganglioneuroma/diagnosis; Ganglioneuroma/surgery; Humans; Hyperthermia, Induced; Lymphocytes, Tumor-Infiltrating/immunology; Measles-Mumps-Rubella Vaccine/immunology; Multiple Sclerosis/diagnosis; Neoplasm Recurrence, Local/drug therapy; Neoplasm Recurrence, Local/radiotherapy; Neoplasm Recurrence, Local/surgery; Neoplasms, Multiple Primary/diagnosis; Neoplasms, Multiple Primary/surgery; Neuroblastoma/diagnosis; Neuroblastoma/immunology; Neuroblastoma/therapy; Optic Atrophy/diagnosis; Optic Atrophy/etiology; Paraneoplastic Syndromes, Nervous System/diagnostic imaging; Paraneoplastic Syndromes, Nervous System/immunology; Peripheral Blood Stem Cell Transplantation; Radionuclide Imaging; Radiotherapy, Adjuvant; Retroperitoneal Neoplasms/diagnosis; Retroperitoneal Neoplasms/immunology; Retroperitoneal Neoplasms/therapy; T-Lymphocyte Subsets/immunology; Young Adult
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Full text: 1 Database: MEDLINE Main subject: Para-Aortic Bodies / Retroperitoneal Neoplasms / Autoantibodies / Autoantigens / Survivors / Paraneoplastic Syndromes, Nervous System / Autoimmune Diseases of the Nervous System / ELAV Proteins / Ganglioneuroma / Neoplasms, Multiple Primary Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Language: En Journal: J Neurol Sci Year: 2009 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Main subject: Para-Aortic Bodies / Retroperitoneal Neoplasms / Autoantibodies / Autoantigens / Survivors / Paraneoplastic Syndromes, Nervous System / Autoimmune Diseases of the Nervous System / ELAV Proteins / Ganglioneuroma / Neoplasms, Multiple Primary Type of study: Clinical_trials / Diagnostic_studies / Etiology_studies / Risk_factors_studies Language: En Journal: J Neurol Sci Year: 2009 Type: Article Affiliation country: Germany