An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis.

Kälin, Roland E; Bänziger-Tobler, Nadja E; Detmar, Michael; Brändli, André W

Kälin, Roland E; Bänziger-Tobler, Nadja E; Detmar, Michael; Brändli, André W.

Affiliation

Kälin RE; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, CH-8093 Zürich, Switzerland.

Blood ; 114(5): 1110-22, 2009 Jul 30.

Article in En | MEDLINE | ID: mdl-19478043

Subject(s)

Biological Factors/isolation & purification; In Situ Hybridization/methods; Lymphangiogenesis/physiology; Neovascularization, Physiologic/physiology; Small Molecule Libraries; Xenopus laevis/metabolism; Adenosine A1 Receptor Antagonists; Adrenergic alpha-Antagonists/isolation & purification; Adrenergic alpha-Antagonists/pharmacology; Animals; Biological Factors/pharmacology; Biological Factors/physiology; Cells, Cultured/drug effects; Drug Evaluation, Preclinical; Edema/etiology; Embryo, Nonmammalian; Endothelial Cells/drug effects; Female; Humans; Larva; Mice; Naphthyridines/isolation & purification; Naphthyridines/pharmacology; Neovascularization, Physiologic/drug effects; Phenotype; Vascular Endothelial Growth Factor A/antagonists & inhibitors; Xenopus laevis/embryology; Xenopus laevis/growth & development

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Full text: 1 Database: MEDLINE Main subject: Xenopus laevis / Biological Factors / In Situ Hybridization / Neovascularization, Physiologic / Lymphangiogenesis / Small Molecule Libraries Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Blood Year: 2009 Type: Article Affiliation country: Switzerland

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