DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats.

Sato, K; Iemitsu, M; Aizawa, K; Ajisaka, R

Sato, K; Iemitsu, M; Aizawa, K; Ajisaka, R.

Affiliation

Sato K; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Acta Physiol (Oxf) ; 197(3): 217-25, 2009 Nov.

Article in En | MEDLINE | ID: mdl-19523145

Subject(s)

Dehydroepiandrosterone/pharmacology; Diabetes Mellitus, Experimental/metabolism; Glucose Transporter Type 4/drug effects; Hyperglycemia/metabolism; Muscle, Skeletal/drug effects; Proto-Oncogene Proteins c-akt/drug effects; Adjuvants, Immunologic; Animals; Blood Glucose/drug effects; Diabetes Mellitus, Experimental/drug therapy; Enzyme Activation/drug effects; Enzyme-Linked Immunosorbent Assay; Glucose Transporter Type 4/metabolism; Immunoblotting; Male; Muscle, Skeletal/metabolism; Protein Kinase C/drug effects; Protein Kinase C/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Rats; Rats, Wistar; Signal Transduction/drug effects

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Full text: 1 Database: MEDLINE Main subject: Dehydroepiandrosterone / Muscle, Skeletal / Diabetes Mellitus, Experimental / Proto-Oncogene Proteins c-akt / Glucose Transporter Type 4 / Hyperglycemia Language: En Journal: Acta Physiol (Oxf) Year: 2009 Type: Article Affiliation country: Japan

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