The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells.

Ma, Yonggang; Wink, Michael

Ma, Yonggang; Wink, Michael.

Affiliation

Ma Y; University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology, INF 364, 69120 Heidelberg, Germany.

Phytother Res ; 24(1): 146-9, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19548284

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Camptothecin/pharmacology; Harmine/pharmacology; Mitoxantrone/pharmacology; Neoplasm Proteins/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Line, Tumor; Drug Resistance, Multiple/drug effects; Drug Resistance, Neoplasm/drug effects; Humans; Multidrug Resistance-Associated Proteins/metabolism

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Camptothecin / Mitoxantrone / ATP-Binding Cassette Transporters / Harmine / Neoplasm Proteins Language: En Journal: Phytother Res Year: 2010 Type: Article Affiliation country: Germany

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google