[Maintenance effect of polyglycosides of Tripterygium wilfordii on remission in postoperative Crohn disease].
Zhonghua Wei Chang Wai Ke Za Zhi
; 12(5): 491-3, 2009 Sep.
Article
in Zh
| MEDLINE
| ID: mdl-19742342
ABSTRACT
OBJECTIVE:
To observe the maintenance effect of polyglycosides of Tripterygium wilfordii (GTW) on remission in postoperative Crohn disease (CD).METHODS:
From 2005 to 2007, 45 adult cases of postoperative Crohn disease were randomly divided into two groups, GTW group and mesalazine group, which received GTW and mesalazine treatment respectively. CD activity index (CDAI) and clinical markers were collected at 0, 3, 6, 12 months or at the onset of symptoms. Ileocolonoscopy was performed at the end of the trial (1 year after operation) or at the onset of symptoms, and recurrence score were recorded.RESULTS:
No clinical recurrence was ascertained in both groups at 3 months. Four patients (18.2%) in GTW group relapsed and 5 (21.7%) in mesalazine group relapsed at 6 months (P=0.530). Seven patients (31.8%) in GTW group and 9 (39.1%) in mesalazine group relapsed at one year (P=0.421). Ten patients (45.5%) in GTW group had endoscopic recurrence compared with 14 (60.9%) in mesalazine group at one year(P=0.231). There were no significant differences between two groups.CONCLUSION:
GTW is similar to mesalazine in maintenance of remission of postoperative Crohn disease.
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Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
Main subject:
Crohn Disease
/
Tripterygium
/
Glycosides
/
Phytotherapy
Type of study:
Clinical_trials
Language:
Zh
Journal:
Zhonghua Wei Chang Wai Ke Za Zhi
Year:
2009
Type:
Article
Affiliation country:
China