Chronic NMDA administration to rats increases brain pro-apoptotic factors while decreasing anti-Apoptotic factors and causes cell death.

Kim, Hyung-Wook; Chang, Yunyoung C; Chen, Mei; Rapoport, Stanley I; Rao, Jagadeesh S

Kim, Hyung-Wook; Chang, Yunyoung C; Chen, Mei; Rapoport, Stanley I; Rao, Jagadeesh S.

Affiliation

Kim HW; Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. kimhyung@mail.nih.gov

BMC Neurosci ; 10: 123, 2009 Sep 28.

Article in En | MEDLINE | ID: mdl-19785755

Subject(s)

Apoptosis/drug effects; Brain-Derived Neurotrophic Factor/metabolism; Cyclic AMP Response Element-Binding Protein/metabolism; Frontal Lobe/metabolism; N-Methylaspartate/administration & dosage; Proto-Oncogene Proteins c-bcl-2/metabolism; Animals; Blotting, Western; Excitatory Amino Acid Agonists/administration & dosage; Frontal Lobe/drug effects; Injections, Intraperitoneal; Male; Phosphorylation/drug effects; RNA, Messenger/metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Subcellular Fractions

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Full text: 1 Database: MEDLINE Main subject: N-Methylaspartate / Cyclic AMP Response Element-Binding Protein / Apoptosis / Brain-Derived Neurotrophic Factor / Proto-Oncogene Proteins c-bcl-2 / Frontal Lobe Type of study: Etiology_studies / Prognostic_studies Language: En Journal: BMC Neurosci Year: 2009 Type: Article Affiliation country: United States

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