Neoplasms/drug therapy; src-Family Kinases/genetics; src-Family Kinases/metabolism; Actins/metabolism; Animals; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Survival; Clinical Trials as Topic; Crk-Associated Substrate Protein/metabolism; Drug Evaluation, Preclinical; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases/metabolism; Focal Adhesion Protein-Tyrosine Kinases/metabolism; GTPase-Activating Proteins/metabolism; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Integrins/metabolism; MAP Kinase Signaling System; Neoplasm Metastasis/drug therapy; Neoplasms/metabolism; Paxillin/metabolism; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases/metabolism; Signal Transduction; Time Factors; Transcription Factors/metabolism; src-Family Kinases/antagonists & inhibitors; src-Family Kinases/chemistry