KO-202125, a sauristolactam derivate, induces apoptosis to prevent KB human oral squamous carcinoma cells through inhibition of cyclooxygenase-2 expression.

Leem, Dae-Ho; Choi, Kyeong-Hee; Han, Hye-Suk; Kim, Jun-Hee; Shin, Ji-Ae; Choi, Eun-Sun; Shim, Jung-Hyun; Kong, Gu; Min, Yong-Ki; Nam, Jeong-Seok; Oh, Seung Hyun; Kim, Kyoung-A; Kwon, Ki Han; Cho, Nam-Pyo; Cho, Sung-Dae

Leem, Dae-Ho; Choi, Kyeong-Hee; Han, Hye-Suk; Kim, Jun-Hee; Shin, Ji-Ae; Choi, Eun-Sun; Shim, Jung-Hyun; Kong, Gu; Min, Yong-Ki; Nam, Jeong-Seok; Oh, Seung Hyun; Kim, Kyoung-A; Kwon, Ki Han; Cho, Nam-Pyo; Cho, Sung-Dae.

Affiliation

Leem DH; Department of Oral and Maxillofacial Surgery, School of Dentistry and Research of Clinical Medicine, Chonbuk National University, Jeonju, Korea.

Eur J Cancer Prev ; 19(1): 23-30, 2010 Jan.

Article in En | MEDLINE | ID: mdl-19910795

Subject(s)

Apoptosis/drug effects; Carcinoma, Squamous Cell/pathology; Cyclooxygenase 2/genetics; Isoindoles/pharmacology; Mouth Neoplasms/pathology; Alkaloids/chemistry; Alkaloids/pharmacology; Antineoplastic Agents/pharmacology; Carcinoma, Squamous Cell/genetics; Carcinoma, Squamous Cell/metabolism; Celecoxib; Cell Proliferation/drug effects; Cell Survival/drug effects; Cyclooxygenase 2/metabolism; Down-Regulation/drug effects; Drug Evaluation, Preclinical; Gene Expression Regulation, Enzymologic/drug effects; Humans; KB Cells; Lactams/chemistry; Lactams/pharmacology; Mouth Neoplasms/genetics; Mouth Neoplasms/metabolism; Phenanthrenes/chemistry; Phenanthrenes/pharmacology; Pyrazoles/pharmacology; Sulfonamides/pharmacology

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Full text: 1 Database: MEDLINE Main subject: Mouth Neoplasms / Carcinoma, Squamous Cell / Apoptosis / Cyclooxygenase 2 / Isoindoles Language: En Journal: Eur J Cancer Prev Year: 2010 Type: Article

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