Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically achievable concentrations.

Brantley, Scott J; Oberlies, Nicholas H; Kroll, David J; Paine, Mary F

Brantley, Scott J; Oberlies, Nicholas H; Kroll, David J; Paine, Mary F.

Affiliation

Brantley SJ; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7569, USA.

J Pharmacol Exp Ther ; 332(3): 1081-7, 2010 Mar.

Article in En | MEDLINE | ID: mdl-19934397

Subject(s)

Anticoagulants/metabolism; Aryl Hydrocarbon Hydroxylases/metabolism; Silybum marianum/chemistry; Silymarin/analogs & derivatives; Warfarin/metabolism; Anticoagulants/chemistry; Cytochrome P-450 CYP2C9; Herb-Drug Interactions; Humans; Hydroxylation; In Vitro Techniques; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Recombinant Proteins/metabolism; Silybin; Silymarin/chemistry; Silymarin/pharmacology; Stereoisomerism; Warfarin/chemistry

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Silymarin / Warfarin / Aryl Hydrocarbon Hydroxylases / Silybum marianum / Anticoagulants Language: En Journal: J Pharmacol Exp Ther Year: 2010 Type: Article Affiliation country: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google