Potent inhibition of human gastric cancer by HER2-directed induction of apoptosis with anti-HER2 antibody and caspase-3 fusion protein.

Zhang, De-Xin; Zhao, Peng-Tao; Xia, Lin; Liu, Li-Li; Liang, Jie; Zhai, Hui-Hong; Zhang, Hong-Bo; Guo, Xue-Gang; Wu, Kai-Chun; Xu, Yan-Ming; Jia, Lin-Tao; Yang, An-Gang; Chen, Si-Yi; Fan, Dai-Ming

Zhang, De-Xin; Zhao, Peng-Tao; Xia, Lin; Liu, Li-Li; Liang, Jie; Zhai, Hui-Hong; Zhang, Hong-Bo; Guo, Xue-Gang; Wu, Kai-Chun; Xu, Yan-Ming; Jia, Lin-Tao; Yang, An-Gang; Chen, Si-Yi; Fan, Dai-Ming.

Affiliation

Zhang DX; State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, the Fourth Military Medical University, 15 West Chang-Le Road, Xi'an 710032, PR China.

Gut ; 59(3): 292-9, 2010 Mar.

Article in En | MEDLINE | ID: mdl-19951902

Subject(s)

Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Receptor, ErbB-2/immunology; Recombinant Fusion Proteins/therapeutic use; Stomach Neoplasms/drug therapy; Animals; Antibodies, Monoclonal/therapeutic use; Antineoplastic Agents/pharmacology; Caspase 3/therapeutic use; Drug Evaluation, Preclinical/methods; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins/metabolism; Receptor, ErbB-2/metabolism; Recombinant Fusion Proteins/pharmacology; Stomach Neoplasms/metabolism; Stomach Neoplasms/pathology; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

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Full text: 1 Database: MEDLINE Main subject: Stomach Neoplasms / Recombinant Fusion Proteins / Apoptosis / Receptor, ErbB-2 / Antineoplastic Agents Language: En Journal: Gut Year: 2010 Type: Article

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